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Cerebral Hemodynamic Effects of Individualized PEEP During Robotic Prostatectomy

StatusEnrolling by Invitation
PhaseNot applicable
Started
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Record History

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  1. Enrolling by invitation only Show 4 more changesShow less
    • Start date changed from estimate of Aug 19, 2026 to Aug 24, 2026
    • Secondary endpoints: details revised at 6 of 6 entries
    • Site contact updated
    • Eligibility criteria expanded, about 2 words
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This randomized clinical trial will compare two approaches to setting positive end-expiratory pressure (PEEP) during robot-assisted radical prostatectomy performed in the Trendelenburg position. The study aims to determine whether individualized PEEP, selected according to the lowest driving pressure, affects cerebral blood flow and brain oxygenation differently from standard PEEP. Approximately 45 adult patients undergoing robot-assisted radical prostatectomy will be randomly assigned to receive either individualized PEEP or standard PEEP during general anesthesia. Cerebral blood flow will be assessed noninvasively using transcranial Doppler ultrasound, and brain oxygenation will be monitored using near-infrared spectroscopy. Participants will also undergo brief assessments of attention, cognitive function, delirium, and sedation before and after surgery, with follow-up continuing for up to 48 hours after the operation. Both ventilation approaches are routinely used in clinical practice, and no experimental drug, device, or additional invasive procedure will be used as part of the study.
Trial Details
NCT Number NCT07784010
Lead Sponsor Istanbul University
Conditions
(from sponsor)		 Cerebral Hemodynamics, Mechanical Ventilation Strategies, Robotic Prostatectomy
Enrollment 45 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov