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NCT07782827 · ClinicalTrials.gov record · last posted 2026-08-24

CHAMPION: A Study to Evaluate the Efficacy and Safety of Obudanersen (ION582) in Children and Adults With Angelman Syndrome (AS)

Name: CHAMPION: A Study to Evaluate the Efficacy and Safety of Obudanersen (ION582) in Children and Adults With Angelman Syndrome (AS) — clinical trial record (NCT07782827)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

StatusNot Yet Recruiting

PhasePhase 3

SponsorIonis Pharmaceuticals, Inc.

Started2026-09

View on ClinicalTrials.gov ↗

from the ClinicalTrials.gov record

The primary purpose of the study is to evaluate efficacy of obudanersen in participants with AS due to uniparental disomy or imprinting defects (UPD/ID) as measured through expressive communication.

Trial Details

NCT Number	NCT07782827
Lead Sponsor	Ionis Pharmaceuticals, Inc.
Conditions	Angelman Syndrome
Enrollment	30 participants
Start Date	2026-09
Primary Completion	2028-05 (estimated)
Study Completion	2031-05 (estimated)
Updated on ClinicalTrials.gov	2026-08-24