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Phase 1/2 Study of KRRO-121 in Healthy Volunteers and Patients With UCD

Study acronym: ANCHOR
StatusRecruiting
PhasePhase 1/2
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary endpoint reworded 2 of 2 changed
See other at-risk trials from Korro Bio, Inc.

Record History

See every version on ClinicalTrials.gov ↗

  1. Recruitment opened
    • Start date changed from estimate of Sep 2026 to Sep 28, 2026
    • Eligibility criteria expanded, about 9 words
    • Site details revised
  2. Primary endpoint(s) modified
    • Secondary endpoint revised
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Phase 1/2 Study of KRRO-121 is a randomized, placebo-controlled study in Healthy Volunteers (Phase 1 SAD and MAD) and Study Participants with Urea Cycle Disorders (Phase 2). The primary objective of the study is to evaluate the safety of KRRO-121.
Trial Details
NCT Number NCT07773246
Lead Sponsor Korro Bio, Inc.
Conditions
(from sponsor)		 Urea Cycle Disorders, Inborn, Urea Cycle Disorders, Ornithine Transcarbamylase (OTC) Deficiency, Arginase 1 Deficiency, NAGS Deficiency, Carbamylphosphate Synthetase I, Ornithine Transporter Mitochondrial 1, Argininosuccinate Synthase +3 more
Related terms Adult-onset citrullinemia type 2, Argininosuccinic Aciduria, Hyperargininemia, N-acetyl glutamate synthetase deficiency, Ornithine Carbamoyltransferase Deficiency Disease, Urea Cycle Disorders, Inborn
Enrollment 30 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov