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Local and Systemic Inflammatory Bone Alterations Related to Dental Implant Survival.

StatusActive, Not Recruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated August 31, 2026 (before its estimated October 15, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Secondary endpoints: details revised at 5 of 5 entries
    • Study description shortened, about 164 words
    • Publications: 23 to 24
    v2
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Introduction: Dental implants offer a durable, aesthetic, and functional option for tooth replacement. However, they are not immune to failure. Current literature has highlighted the importance of systemic factors (such as vitamin D deficiency, osteoporosis and hypercolesterolemia) and local factors (such as the presence of nearby periapical infections or implant placement in sites with a history of endodontic failure) that affect bone health. Hypothesis: Bone alterations-whether systemic or local-represent a risk factor for implant failure and peri-implantitis. Objectives: To analyze implant failure and marginal bone loss in patients with local and/or systemic bone alterations compared to patients without such conditions. Methods: Implant failures occurring in patients treated within the Master's Program in Oral Medicine, Surgery, and Implantology at the University of Barcelona (MCIO-UB) over the last 10 years will be analyzed and correlated with bone factors (local and systemic) recorded in their medical histories. Cases lacking the radiographic and clinical data necessary to conduct the study will be excluded. Population: A total of 3,500 implants have been placed, with failure rates ranging from 4% to 8% depending on the techniques used; consequently, the study sample will consist of 192 implants. Cohorts of successful implants will be established by matching patients of the same sex and within a ±5-year age range who did not experience implant failure.
Trial Details
NCT Number NCT07766707
Lead Sponsor University of Barcelona
Conditions
(from sponsor)		 Peri Implant Mucositis, Peri Implant Bone Loss, Peri Implantitis, Calcium Deficiency, Phosphorus and Calcium Disorders, Vitamin D Deficiency, Renal Insufficiency / Therapy, Renal Insufficiency Chronic +6 more
Related terms Acute Kidney Injury, Diabetes Mellitus, Kidney Diseases, Peri-Implantitis, Renal Insufficiency, Renal Insufficiency, Chronic, Vitamin D Deficiency
Enrollment 192 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov