Clinical Trial

Dentate-Targeted Temporal Interference Stimulation for Post-Stroke Dysphagia

Study acronym: DENTIS-PSD
Not Yet Recruiting
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Summary
The goal of this clinical trial is to learn whether individualized transcranial temporal interference stimulation can improve swallowing in adults with swallowing difficulties after an ischemic stroke. It will also evaluate the safety and tolerability of this stimulation. The main questions it aims to answer are: * Does active temporal interference stimulation combined with swallowing rehabilitation improve swallowing safety more than sham stimulation combined with the same rehabilitation? * What side effects or medical problems occur during and after the stimulation? Researchers will compare active stimulation with sham stimulation, which uses the same equipment but does not deliver sustained therapeutic stimulation. Participants will: * Receive active or sham stimulation for 30 minutes per session, 5 days per week for 2 weeks * Receive the same task-specific swallowing rehabilitation after each stimulation session * Undergo swallowing assessments, brain imaging, and neurophysiological testing * Attend follow-up assessments 4 and 12 weeks after treatment
Trial Details
NCT Number NCT07766668
Lead Sponsor Zhejiang University
Conditions Deglutition Disorders, Ischemic Stroke
Enrollment 88 participants
Start Date 2026-09-01
Primary Completion 2029-12-30 (estimated)
Study Completion 2030-03-01 (estimated)
Updated on ClinicalTrials.gov 2026-08-14