Clinical Trial

NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC

Study acronym: CRI-KEV
Not Yet Recruiting Phase 2
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Summary
To explore the efficacy and safety of adding a ketogenic diet and/or high-dose intravenous vitamin C to neoadjuvant short-course radiotherapy followed by mFOLFOX6 chemotherapy combined with serplulimab in patients with locally advanced pMMR/MSS rectal adenocarcinoma through a prospective, randomized, controlled phase II clinical study, providing preliminary evidence for optimizing neoadjuvant treatment strategies for this population.
Trial Details
NCT Number NCT07765667
Lead Sponsor Sixth Affiliated Hospital, Sun Yat-sen University
Conditions Rectal Adenocarcinoma, High-Risk Cancer, MSS
Enrollment 100 participants
Start Date 2026-09-01
Primary Completion 2029-09-01 (estimated)
Study Completion 2029-09-01 (estimated)
Updated on ClinicalTrials.gov 2026-08-14