Cold Versus Hot Snare Endoscopic Mucosal Resection for Intermediate-Size Flat Nonpedunculated Colorectal Polyps

This multicenter, prospective, randomized, non-inferiority trial aimed to compare the efficacy and safety of cold snare endoscopic mucosal resection (CS-EMR) and hot snare endoscopic mucosal resection (HS-EMR) for resection of intermediate-size (10-20 mm) flat nonpedunculated colorectal polyps.

NCT Number	NCT07764224
Lead Sponsor	Nanfang Hospital, Southern Medical University Collaborators: Shunde First People's Hospital of Foshan, Jiangmen Central Hospital, ZhuHai Hospital, Longgang District People's Hospital of Shenzhen, Yangjiang People's Hospital, The Third People's Hospital of Huizhou, Longnan Traditional Chinese Medicine Hospital, Sihui Wanlong Hospital, Suixi People's Hospital of Zhanjiang, Guzhen People's Hospital of Zhongshan, Anyuan County People's Hospital of Ganzhou, Shaoguan First People's Hospital, Yangchun People's Hospital, ZhuZhou Central Hospital
Conditions	Colorectal Polyps, Endoscopic Mucosal Resection
Enrollment	968 participants
Start Date	2026-08
Primary Completion	2028-10 (estimated)
Study Completion	2029-02 (estimated)
Updated on ClinicalTrials.gov	2026-08-13