Effect of CSIR-Developed High-Protein, Low-Glycaemic Index Rice on Glycaemic Response in Individuals With Prediabetes

This is a randomized, controlled, two-phase crossover study will be conducted in adults aged 18-60 years with prediabetes to compare the effects of a CSIR-developed high-protein, low-glycaemic index rice with conventional rice. Phase I will evaluate acute postprandial glucose, insulin, C-peptide, GLP-1, and hunger/satiety responses, while Phase II will assess 72-hour continuous glucose monitoring (CGM) outcomes, including mean glucose and glycaemic variability. Eligible participants will be randomly assigned to receive both rice types in a crossover manner, with each participant serving as their own control. Individuals with diabetes, major systemic illnesses, abnormal liver or renal function, pregnancy, or glucose-lowering medication use will be excluded.

NCT Number	NCT07762768
Lead Sponsor	Diabetes Foundation, India Collaborators: National Diabetes, Obesity and Cholesterol Foundation (N-DOC), CSIR National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram
Conditions	Prediabetes
Enrollment	36 participants
Start Date	2026-09-01
Primary Completion	2027-02-15 (estimated)
Study Completion	2027-02-28 (estimated)
Updated on ClinicalTrials.gov	2026-08-13