Clinical Trial

Metabolic Flux Analysis in Metabolic Dysfunction-Associated Steatotic Liver Disease

Study acronym: MASLD
Not Yet Recruiting
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Summary
This prospective, single-center pilot study will evaluate metabolic flux dysregulation in adults with obesity and suspected or confirmed metabolic dysfunction-associated steatotic liver disease (MASLD) who are scheduled for protocol-eligible bariatric surgery at Vanderbilt University Medical Center. Participants will undergo research assessments before surgery, during the planned bariatric surgery encounter, and approximately 6 months after surgery. The study uses non-radioactive stable isotope tracer infusions, serial blood sampling, abdominal MRI/MRE, and research tissue specimens collected only during clinically planned bariatric surgery to quantify hepatic and extrahepatic metabolic fluxes. The primary objective is to determine how hepatic citric acid cycle flux and related metabolic pathways change after bariatric surgery and how these metabolic measures relate to liver fat, liver stiffness, and biopsy-graded MASLD/MASH severity.
Trial Details
NCT Number NCT07760909
Lead Sponsor Vanderbilt University Medical Center
Conditions Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis, Obesity, Bariatric Surgery
Enrollment 20 participants
Start Date 2026-10-01
Primary Completion 2029-09-30 (estimated)
Study Completion 2060-01-01 (estimated)
Updated on ClinicalTrials.gov 2026-08-12