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Effects of Agent-assisted, LLM-assisted and Traditional Workflows on Diagnosis and Management Planning at Admission

StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary endpoint reworded 1 of 1 changed
See other at-risk trials from Second Affiliated Hospital, Zhejiang University, School of Medicine

Record History

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  1. Notable Recruitment opened
    • Secondary endpoints: details revised at 2 of 2 entries
  2. Notable Trial status: Not Yet Recruiting to Recruiting Show 5 more changesShow less
    • Start date changed from estimate of Aug 2026 to Sep 6, 2026
    • Eligibility criteria expanded, about 11 words
    • Secondary endpoints: details revised at 2 of 2 entries
    • Site details revised
    • Collaborators: details revised at 1 of 1 entry
  3. Notable Primary endpoint(s) modifiedv2 Show 5 more changesShow less
    • Start date: Sep 2026 to Aug 2026
    • Interventions: Agent Workflow (Other), LLM Workflow (Other), traditional workflow (Other) to Agent-assisted workflow (Other), LLM-assisted workflow (Other), Traditional Workflow (Other)
    • Eligibility criteria shortened, about 57 words
    • Secondary endpoints: 3 to 2
    • Study title expanded, about 3 words
  4. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this clinical trial is to evaluate whether AI-assisted workflows improve physicians' admission diagnosis and management planning performance on standardized simulated inpatient cases, among practicing internal medicine and surgery physicians across all seniority levels and across three tiers of the Chinese healthcare system. The main questions it aims to answer are: * Does the Agent-assisted workflow yield better structured admission diagnosis and management planning scores than standalone LLM assistance? * Does the Agent-assisted workflow outperform the traditional workflow without AI tools? Researchers will compare three parallel groups (traditional workflow group, LLM-assisted group, Agent-assisted group) to determine whether the Agent tool can improve diagnostic accuracy and efficiency. The goal of this clinical trial is to evaluate whether AI-assisted workflows improve physicians' admission diagnosis and management planning performance on standardized simulated inpatient cases, among practicing internal medicine and surgery physicians across all seniority levels and across three tiers of the Chinese healthcare system. The main questions it aims to answer are: * Does the Agent-assisted workflow yield better diagnosis and management planning scores than the LLM-assisted workflow? * Does the Agent-assisted workflow yield better diagnosis and management planning scores than the conventional workflow without AI assistance? Researchers will compare three parallel groups (traditional workflow group, LLM-assisted group, Agent-assisted group) to determine whether the agent tool can improve diagnostic and management planning performance and efficiency. Participants will: * Be recruited from 15 hospitals in China and participate remotely under video proctoring * Be randomly assigned to one of the three fixed workflows, with randomization stratified by hospital tier, specialty and seniority * Work through 6 anonymized simulated HIS admission cases and complete as many as they can. * Submit structured answers for each case covering principal diagnosis, secondary diagnoses, differential diagnoses, diagnostic justification, next diagnostic or therapeutic steps, consultation and referral decisions, and diagnostic confidence. * Have their operation logs and time consumption recorded automatically by the study platform. * Complete a post-session questionnaire after submitting all cases.
Trial Details
NCT Number NCT07760051
Lead Sponsor Second Affiliated Hospital, Zhejiang University, School of Medicine
Collaborators: Shangrao People's Hospital
Conditions
(from sponsor)
Clinical Decision Support Systems, Diagnostic Reasoning, Artificial Intelligence (AI)
Enrollment 180 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov