Underwater Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Small Rectal Neuroendocrine Tumors

Underwater endoscopic mucosal resection (UEMR) and endoscopic submucosal dissection (ESD) have both been reported to be two effective treatment methods for small rectal neuroendocrine tumor (NET). However, there is no consensus on the best method for the endoscopic resection of rectal NET. Therefore, we aimed to compare the efficacy and safety of UEMR and ESD for the treatment of small rectal NET.

NCT Number	NCT07759960
Lead Sponsor	Nanfang Hospital, Southern Medical University Collaborators: Guangdong Provincial Hospital of Traditional Chinese Medicine, The Eighth Affiliated Hospital of Southern Medical University, ZhuHai Hospital, Shenzhen Longgang District People's Hospital, Jiangmen Central Hospital, Yangjiang People's Hospital, The Third People's Hospital of Huizhou, the Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai), Ganzhou City People's Hospital
Conditions	Rectal Neuroendocrine Tumor
Enrollment	174 participants
Start Date	2026-04-14
Primary Completion	2029-10 (estimated)
Study Completion	2029-12 (estimated)
Updated on ClinicalTrials.gov	2026-08-12