Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance

The goal of this clinical trial is to examine the effects of duloxetine on walking ability and physical activity in patients with knee osteoarthritis. Researchers will compare duloxetine to a placebo (a look-alike substance that contains no drug) to see if duloxetine works to improve walking ability in patients with knee osteoarthritis. At study visits, participants will complete surveys, perform physical function tasks, undergo non-invasive brain imaging, and undergo sensory testing.

NCT Number	NCT07759336
Lead Sponsor	Benedict Alter Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions	Knee Osteoarthritis (Knee OA), Chronic Pain, Chronic Knee Pain
Enrollment	85 participants
Start Date	2026-08
Primary Completion	2028-08 (estimated)
Study Completion	2028-08 (estimated)
Updated on ClinicalTrials.gov	2026-08-12