Lifestyle Modification for Erectile Dysfunction in Men With Metabolic Syndrome

Metabolic syndrome is associated with erectile dysfunction through obesity, insulin resistance, abnormal blood lipids, high blood pressure, and impaired blood-vessel function. This study will evaluate whether a structured six-month lifestyle-modification program can improve penile blood flow and erectile function in men with metabolic syndrome-associated erectile dysfunction. Eligible participants will receive dietary counseling, exercise guidance, weight-management advice, smoking-cessation counseling when applicable, sleep and sedentary-behavior advice, and repeated behavioral reinforcement. Erectile function, penile blood-flow measurements obtained by penile duplex Doppler ultrasonography, body measurements, and selected metabolic laboratory parameters will be assessed before the program and after six months.

NCT Number	NCT07758842
Lead Sponsor	Al-Azhar University
Conditions	Erectile Dysfunction, Metabolic Syndrome
Enrollment	55 participants
Start Date	2026-08-13
Primary Completion	2027-07-24 (estimated)
Study Completion	2027-11-24 (estimated)
Updated on ClinicalTrials.gov	2026-08-14