Implementation of New Models of Ovarian Carcinoma Resistant to Therapy

The project focuses on developing new experimental models of ovarian cancer that accurately reflect patients who do not respond to first-line platinum-based treatments and who are resistant to PARP inhibitors (PARPi). These models are essential for testing new drugs or drug combinations in preclinical settings that closely mimic real clinical conditions. These models will also help to identify predictive biomarkers of treatment response and to better understand the biological mechanisms behind therapy resistance.

NCT Number	NCT07757711
Lead Sponsor	Mario Negri Institute for Pharmacological Research Collaborators: Istituto Europeo di Oncologia
Conditions	Ovarian Cancer
Enrollment	50 participants
Start Date	2026-08-01
Primary Completion	2036-08-31 (estimated)
Study Completion	2036-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-11