Romosozumab Versus Denosumab In Glucocorticoid-induced Osteoporosis: An Extended Observation Of a Clinical Trial at 6 Years

This is an extended observation study of a RCT comparing the efficacy of romorozumab and denosumab in high-risk patients using long-term glucocorticoids. In the romosozumab arm, patients were shifted to denosumab after the first year. The denosumab arm of patients were continued on denosumab. This study aims to look at the bone mineral density changes in both groups of patients after 6 years.

NCT Number	NCT07757373
Lead Sponsor	Tuen Mun Hospital
Conditions	Glucocorticoid-Associated Osteopenia and Osteoporosis
Enrollment	54 participants
Start Date	2026-09-01
Primary Completion	2027-09-30 (estimated)
Study Completion	2027-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-12