A Research Study to See How NNC0487-0111 Affects the Body's Energy Use After a Weight Loss in Adults Living With Obesity, Compared to a Low-calorie Diet or Placebo

The purpose of this clinical study is to evaluate how NNC0487-0111 affects the amount of energy the body uses in people living with obesity following weight loss. This will be compared with the amount of energy used by participants who achieve weight loss through a low-calorie diet and by participants receiving placebo (without weight loss).

NCT Number	NCT07757087
Lead Sponsor	Novo Nordisk A/S
Conditions	Overweight, Obesity
Enrollment	120 participants
Start Date	2026-08-03
Primary Completion	2028-09-18 (estimated)
Study Completion	2028-09-18 (estimated)
Updated on ClinicalTrials.gov	2026-08-11