Clinical Trial

The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults

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Summary
This study will be a randomized, double-blind, placebo-controlled trial. It will be conducted over a 8-week intervention investigating the effects of creatine (5g Creatine monohydrate); placebo control (5g resistant dextrin), and a combination group containing both creatine and tyrosol (5g creatine monohydrate + 150mg tyrosol/day). Endurance, strength, cognition, and fatigue resistance will be examined through repeated strength and endurance testing (described below). Participants who pass initial screening will be invited on-site for day one (Visit 1) of testing where they will proceed with a series of tests which will include the following: (1) body composition; (2) mood and cognitive testing; (3) full-body strength testing; (4) 5RM (repetition maximum) bench press, leading to multiple sets of bench press (based on the previous weight) completed to failure; (5) finally, a time to exhaustion endurance test will be conducted followed by (6) repeat cognitive testing. After the 8-week supplementation period (\~56-60 days), all original measures will be repeated as before in the same order (Visit 2). Approximately 24 hours later (Visit 3) participants will complete a questionnaire for muscle soreness remotely, and again at 48 hours post-Visit 2 (visit 4).
Trial Details
NCT Number NCT07756658
Lead Sponsor Applied Science & Performance Institute
Conditions Tyrosol, Creatine, Endurance Performance, Cognition, Mood
Enrollment 60 participants
Start Date 2026-08-17
Primary Completion 2026-12-17 (estimated)
Study Completion 2026-12-17 (estimated)
Updated on ClinicalTrials.gov 2026-08-11