Prophylactic Mesh Reinforcement Versus Primary Closure After Emergency Midline Laparotomy (PREEMPT)

The PREEMPT trial is a multicenter randomized controlled trial comparing prophylactic onlay biosynthetic mesh reinforcement with primary suture closure in adult patients undergoing emergency midline laparotomy. Participants will be randomized in a 1:1 ratio. The primary endpoint is the incidence of incisional hernia at 1 year. Secondary endpoints include postoperative complications, surgical site occurrences, pain, operative time, hospital stay, morbidity, mortality, quality of life, and long-term hernia incidence.

NCT Number	NCT07753551
Lead Sponsor	University of Rome Tor Vergata Collaborators: Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo, San Filippo Neri General Hospital, San Giovanni Addolorata Hospital, Santa Maria della Pieta Hospital - Nola, Buccheri La Ferla Hospital, Palermo, Cardarelli Hospital, Naples, Italy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions	Incisional Hernia After Midline Laparotomy, Emergency Abdominal Surgery
Enrollment	189 participants
Start Date	2026-09-01
Primary Completion	2029-08-31 (estimated)
Study Completion	2031-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-07