Young Onset Parkinson's Disease Subtypes and Pathogenic Mechanisms

Young Onset Parkinson's disease (YOPD) refers to a group of patients in which the disease starts earlier in life (before the age of 50 years) and has a profound impact on most of patient's life. Current knowledge regarding the mechanisms leading to development of Parkinson's disease in younger individuals is lacking, but their understanding is crucial for the successful design of therapeutic strategies and stratifying patients for clinical trials. With this research the investigators aim to clarify the contribution of relevant biological processes in patients with Young onset Parkinson's disease to help understanding disease mechanisms and biomarkers.

NCT Number	NCT07752355
Lead Sponsor	NYU Langone Health Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions	Young Onset Parkinson Disease, Parkinson Disease
Enrollment	250 participants
Start Date	2024-02-28
Primary Completion	2028-10-31 (estimated)
Study Completion	2028-10-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-12