Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals

Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with overweight or obesity. Secondary objective is to assess the effects of 12-week daily avocado consumption on brain insulin sensitivity after intranasal insulin delivery, vascular function, markers of metabolic health, cognition, and psychological well-being. For that purpose a total of 34 men and women between the ages of 40-75 years old, will participate in a randomised crossover intervention study.

NCT Number	NCT07752225
Lead Sponsor	Maastricht University Medical Center Collaborators: Avocado Nutrition Center
Conditions	Prediabetes, Brain Insulin Sensitivity, Cerebral Blood Flow, Satiety and Food Intake, Food Reward, Brain Health, Vascular Function, Obesity & Overweight
Enrollment	34 participants
Start Date	2026-09-01
Primary Completion	2028-06-30 (estimated)
Study Completion	2028-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-07