FORWARD: Functional Outcomes in Real-World Treatment And Revascularization of Non-dominant and Distal M2 Occlusions

The objective of this study is to collect safety and effectiveness data on the Penumbra System reperfusion catheters in participants with isolated primary non-dominant and distal M2 occlusions who undergo endovascular mechanical thrombectomy (EVT). Additionally, this study aims to observe characteristics and outcomes of participants treated with medical management (MM) alone and those who receive EVT + MM per current medical practice.

NCT Number	NCT07749170
Lead Sponsor	Penumbra Inc.
Conditions	Acute Ischemic Stroke, Acute Ischemic Stroke (AIS) Related to a Distal Occlusion
Enrollment	250 participants
Start Date	2026-06-26
Primary Completion	2028-09 (estimated)
Study Completion	2028-09 (estimated)
Updated on ClinicalTrials.gov	2026-08-06