Blood Transfusion Strategies During Major Surgery

Study acronym: TOPGUN
StatusRecruiting
PhaseNot applicable
Started

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Record History

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  1. Recruitment opened Show 4 more changesShow less
    • Start date changed from estimate of Aug 19, 2026 to Sep 2, 2026
    • Eligibility criteria expanded, about 14 words
    • Secondary endpoints: details revised at 4 of 11 entries
    • Site details revised at 2 of 2 sites
  2. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
The goal of this randomized clinical trial is to address the uncertainty surrounding blood transfusion strategies in the operating room for adult patients undergoing major surgery. The main question it aims to answer is: Does a higher hemoglobin threshold for blood transfusion during surgery reduce the risk of serious complications or death after surgery compared with a lower hemoglobin threshold? Researchers will compare a liberal and a restrictive transfusion strategy during surgery and the first few hours of recovery. Participants will be randomly assigned to one of two blood transfusion strategies. Blood transfusions will be given to maintain either a higher hemoglobin level (90-100 g/L) or a lower hemoglobin level (70-80 g/L) during surgery and while in the recovery room after surgery. Participants will also complete questionnaires about their quality of life and recovery at 30 and 90 days after surgery.
Trial Details
NCT Number NCT07748663
Lead Sponsor Ottawa Hospital Research Institute
Conditions
(from sponsor)		 Perioperative Red Blood Cell Transfusion
Enrollment 5,058 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov