Network Modeling in Knee Osteoarthritis

This project seeks to understand inter-individual differences in chronic musculoskeletal pain (cMSKP). Our long-term objective is to develop clinically-feasible decision tools that enable whole-person assessment and management of cMSKP and guide personalized primary, secondary and tertiary prevention strategies. Our secondary objective is to understand how inter-relationships between physiological, biomechanical and psychosocial factors change over time and impact the experience of living with chronic pain.

NCT Number	NCT07746284
Lead Sponsor	George Mason University Collaborators: National Center for Complementary and Integrative Health (NCCIH)
Conditions	Chronic Musculoskeletal Pain
Enrollment	200 participants
Start Date	2026-03-13
Primary Completion	2029-07-31 (estimated)
Study Completion	2029-08 (estimated)
Updated on ClinicalTrials.gov	2026-08-05