Study on the Management of COMISA

COMISA, the combination of obstructive sleep apnea (OSA) and insomnia, is a frequent and burdensome condition. Many patients with OSA experience clinically significant insomnia symptoms, and a substantial proportion of individuals with chronic insomnia also meet criteria for OSA. This comorbidity is associated with more severe symptoms, more complex diagnostic pathways, and reduced adherence to continuous positive airway pressure (CPAP) therapy. This study aims to better understand COMISA and evaluate whether adding daridorexant to CPAP treatment can improve treatment adherence and overall patient outcomes.

NCT Number	NCT07743931
Lead Sponsor	University Hospital, Grenoble Collaborators: Polyclinique Saint-Laurent - Hospitalité Saint-Thomas de Villeneuve, Hôpital Européen Marseille, Centre Médical les Jasmins "Poumon et Sommeil", Hôpital de la Pitié Salpêtrière - AP-HP
Conditions	Obstructive Sleep Apnea (OSA), Insomnia, COMISA
Enrollment	150 participants
Start Date	2026-08
Primary Completion	2028-06 (estimated)
Study Completion	2029-02 (estimated)
Updated on ClinicalTrials.gov	2026-08-04