Percutaneous Versus EUS-guided Drainage of Symptomatic Fluid Collections After Left Pancreatectomy

Fluid collections are a complication after pancreatic surgery. These fluid collections can be treated with two treatment options. One option is percutaneous drainage, where an external drainage tube is placed in the collection. The second option is endoscopic ultrasound-guided drainage (EUS) with a stent. Both options have similar results in previous clinical studies, but they have not been directly compared in a randomized clinical trial. The goal of this clinical trial is to compare percutaneous drainage with EUS-guided drainage. The main questions it aims to answer are: * Is EUS-guided drainage of symptomatic fluid collections non-inferior to percutaneous catheter drainage in terms of safety? * Is EUS-guided drainage superior in terms of 30-day quality of life, compared to percutaneous drainage? Researchers will compare EUS-guided drainage with percutaneous drainage to see if they are similar in safety outcomes and different in quality-of-life outcomes. Participants will: * Be randomized between percutaneous drainage and EUS-guided drainage. * Fill-out surveys and pain score when they start the study, and then after 1 week and 3 months. * Fill-out an extra pain score on day 1 and day 3. * Receive a phone call from the study team after 1 month, where they will be asked how they are doing. Together with the study team member they fill out the surveys that are taken after 1 month.

NCT Number	NCT07743762
Lead Sponsor	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Collaborators: Azienda Ospedaliera Universitaria Integrata Verona, Leiden University Medical Center, Radboud University Medical Center, St. Antonius Hospital, OLVG, University Medical Center Groningen, Maastricht University Medical Center, Medisch Spectrum Twente, Catharina Ziekenhuis Eindhoven, University Hospital Heidelberg, Erasmus Medical Center, IRCCS San Raffaele, Orlando Health, Inc., Universitaire Ziekenhuizen KU Leuven, University Hospital, Ghent
Conditions	Symptomatic Fluid Collection(s)
Enrollment	96 participants
Start Date	2026-08-01
Primary Completion	2029-11-01 (estimated)
Study Completion	2030-05-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-04