Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention

The purpose of this study is to compare the effect of a brief family-based psychosocial intervention that addresses modifiable SSD risk factors on persistent and distressing psychotic-like experiences in children and young adults with a family history of SSD and high versus low baseline SSD-like brain patterns

NCT Number	NCT07743645
Lead Sponsor	The University of Texas Health Science Center, Houston Collaborators: National Institutes of Health (NIH)
Conditions	Prevention, Risk Factors for Mental Illness, Family History of Schizophrenia Spectrum Disorder
Enrollment	100 participants
Start Date	2026-10-01
Primary Completion	2031-04-01 (estimated)
Study Completion	2031-04-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-04