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N-AD: Orally Administered Nicotinamide Riboside Over Two Years as a Potential Disease Modifying Treatment for Alzheimer's Disease

Study acronym: N-AD
StatusRecruiting
PhasePhase 2
Started2026-08-26
View on ClinicalTrials.gov ↗

Amendment history

2026-08-19
notable
Study Status, Contacts/Locations v2
Recruitment opened
Start date2026-08-15→2026-08-26
Study sitesdetails revised at 2 of 2 sites
2026-08-10
minor
Study Identification, Study Status v1
Study title-81 characters
N-AD: A Randomized, Double Blind, Parallel Group, Placebo Controlled, Phase 2 Trial of Orally Administered Nicotinamide Riboside Over Two Years as [...]
2026-07-28
minor
Original filing
The goal of this clinical trial is to learn if orally administered nicotinamide riboside works to slow the progression of early Alzheimer disease in adults. It will also learn about the safety of drug nicotinamide riboside. The main questions it aims to answer are: * Does drug nicotinamide riboside slow the progression of Alzheimer disease as measured by the Clinical Dementia Rating scale. * What medical problems do participants have when taking drug nicotinamide riboside? Researchers will compare drug nicotinamide riboside to a placebo (a look-alike substance that contains no drug) to see if nicotinamide riboside works to treat early Alzheimer disease. Participants will: * Take drug nicotinamide ribosie or a placebo every day for 24 months * Visit the clinic once every 26 weeks for checkups and tests
Trial Details
NCT Number NCT07741071
Lead Sponsor Haukeland University Hospital
Conditions Alzheimer Disease (AD)
Enrollment 270 participants
Start Date 2026-08-26
Primary Completion 2030-04-30 (estimated)
Study Completion 2030-04-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-20