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Effect of Intraoperative Tetracycline on Postoperative Pain After Mandibular Molar Extraction

Study acronym: TETRAMOL
StatusActive, Not Recruiting
PhasePhase 4
Started
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Record status
This record was last updated September 14, 2026 (before its estimated September 23, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Primary completion date: Jan 23, 2026 to Sep 23, 2026
    • Sponsor refiled this as active, not recruiting (was completed)
    • Study completion date: Jun 28, 2026 to Oct 28, 2026
    v4
  2. Re-verified, no change to tracked fieldsv3
  3. Eligibility criteria revisedv2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Postoperative pain is a common complication following mandibular molar extraction and can negatively affect patient comfort and recovery. Tetracycline is a broad-spectrum antibiotic with anti-inflammatory properties that may reduce postoperative inflammation and pain when applied locally to the extraction socket. This randomized controlled trial aims to evaluate the effect of intraoperative placement of tetracycline on postoperative pain in patients undergoing surgical extraction of mandibular molars. A total of 74 eligible patients will be randomly assigned to receive either intrasocket tetracycline or no local medicament following tooth extraction. All participants will receive the same standard postoperative care and analgesic regimen. Postoperative pain will be assessed using the Visual Analog Scale (VAS) at 24 hours, 48 hours, and 7 days after surgery. The findings of this study will provide evidence regarding the effectiveness of local tetracycline in reducing postoperative pain and may help improve postoperative pain management following mandibular molar extraction.
Trial Details
NCT Number NCT07738861
Lead Sponsor CMH Lahore Medical College and Institute of Dentistry
Conditions
(from sponsor)		 Postoperative Pain, Mandibular Molar Extraction, Tooth Extraction
Related terms Postoperative Pain
Enrollment 74 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov