Ultrasound-Guided Dry Needling, Lidocaine Injection, and Oxygen-Ozone Therapy for Myofascial Pain Syndrome

Prospective, assessor-blinded, randomized controlled trial comparing ultrasound-guided dry needling, lidocaine injection, and oxygen-ozone injection in patients with myofascial pain syndrome (MPS) of the upper trapezius muscle. 76 participants received weekly injections/needling for 3 sessions plus a standardized home exercise program, with clinical (pain, function, sleep, quality of life) and ultrasonographic (tissue imaging, blood flow waveform) outcomes assessed at baseline, Week 4, and Week 12.

NCT Number	NCT07738783
Lead Sponsor	Derince Training and Research Hospital Collaborators: Sivas Numune Hospital, Dokuz Eylul University
Conditions	Myofascial Pain Syndrome (Upper Trapezius)
Enrollment	76 participants
Start Date	2025-06-17
Primary Completion	2026-05-22 (estimated)
Study Completion	2026-05-22 (estimated)
Updated on ClinicalTrials.gov	2026-07-31