Mechanisms Underlying Late-Life Prolonged Grief Disorder

After losing a loved one, most successfully navigate acute grief and adapt to the loss within about 1 year, but in about 10%, prolonged grief disorder (PGD) ensues. This study is anticipated to provide novel evidence regarding the neurobiological mechanisms of PGD in older adults. The biological alterations identified here could provide targets to elucidate how currently available therapies work and inform novel mechanism-based interventions for treating late-life PGD.

NCT Number	NCT07738133
Lead Sponsor	Medical College of Wisconsin
Conditions	Prolonged Grief Disorder
Enrollment	126 participants
Start Date	2027-01
Primary Completion	2031-01 (estimated)
Study Completion	2031-06 (estimated)
Updated on ClinicalTrials.gov	2026-07-31