Progesterone Luteal Support in Unexplained Infertility Management

The purpose of this study is to evaluate whether progesterone in women with unexplained infertility can increases live birth rate. The main research question is: Does luteal phase support with progesterone increase the live birth rate among couples with unexplained infertility? The study compares progesterone with placebo to determine the effectiveness of progesterone in unexplained infertility. Study participants will: * Perform home ovulation tests and maintain a digital diary to record menstrual cycles and study medication use.10 * Take progesterone or placebo twice daily during the luteal phase of each menstrual cycle for up to six months.11 * Continue usual medical care. No additional hospital visits or invasive procedures are required as part of the study.

NCT Number	NCT07738068
Lead Sponsor	Simone Broer Collaborators: ZonMw: The Netherlands Organisation for Health Research and Development
Conditions	Infertility, Female Infertility, Subfertility, Infertility Primary, Infertility Secondary, Subfertility, Female
Enrollment	640 participants
Start Date	2026-08-01
Primary Completion	2030-08-01 (estimated)
Study Completion	2031-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-30