Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes

This study aims to prospectively validate the diagnostic accuracy of an effort-stratified Cough Peak Flow (CPF) decision algorithm for predicting extubation failure, maintaining strict blinding of the clinical team. The model classifies patients by neurological status and uses an effort-based approach, including a "Gray Zone" (40-59 L/min) managed by tidal volume evaluation.

NCT Number	NCT07737483
Lead Sponsor	Hospital H+ Queretaro
Conditions	Extubation Failure
Enrollment	150 participants
Start Date	2026-07-01
Primary Completion	2026-10-01 (estimated)
Study Completion	2026-11-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-30