Research Title: Long Term Functional Outcome of a Single Hyaluronic Acid Injection in Improving Symptoms and Function in Patients With Knee Osteoarthritis - A Single-Arm Open-Label Study (DIART ONE).

This study aims to evaluate the effectiveness of a single HA injection in improving pain, function, and quality of life in patients with knee OA over a 12-month period. By focusing on a single-arm open-label design, this study will provide practical insights into the real-world application of this treatment approach.

NCT Number	NCT07736781
Lead Sponsor	Universiti Sains Malaysia Collaborators: Hospital Universiti Sains Malaysia
Conditions	Osteo Arthritis of the Knee
Enrollment	62 participants
Start Date	2026-08-30
Primary Completion	2028-08-30 (estimated)
Study Completion	2029-08-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-30