Immune Response to PSF in Idiopathic vs Neuromuscular Scoliosis

The objective of this study is to evaluate the immune response to posterior spinal fusion (PSF) in patients with neuromuscular scoliosis, comparing patients with idiopathic scoliosis who undergo the same procedure. This will be accomplished using serum biomarkers of immune response. Anecdotally, it appears that patients with neuromuscular scoliosis have more fluid resuscitation needs compared to patients with idiopathic scoliosis. The proposed hypothesis of this observation is that patients with neuromuscular scoliosis have a more profound immune response compared to patients with idiopathic scoliosis, which leads to a more robust systematic inflammatory response syndrome.

NCT Number	NCT07734467
Lead Sponsor	Ambrish Patel
Conditions	Posterior Spinal Fusion, Idiopathic Scoliosis, Neuromuscular Scoliosis
Enrollment	20 participants
Start Date	2026-10
Primary Completion	2029-06 (estimated)
Study Completion	2029-12 (estimated)
Updated on ClinicalTrials.gov	2026-08-06