Validation of a Capillary Leak Index During Septic Shock, Based on Haemoglobin Level Variations Induced by Fluid Resuscitation. A Pilot Study.

This study aims to validate a simple and reproducible index of capillary leak (CLI) in septic shock, based on haemoglobin (Hb) variation induced by standardised fluid resuscitation. To achieve this, the correlation between CLI and biomarkers of endothelial dysfunction-angiopoietin-2 and syndecan-1-will be assessed in both septic and non-septic shock patients. CLI may contribute to the individualisation of fluid management in patients with septic shock.

NCT Number	NCT07733206
Lead Sponsor	University Hospital Center of Martinique
Conditions	Sepsis
Enrollment	100 participants
Start Date	2026-09-15
Primary Completion	2028-10-15 (estimated)
Study Completion	2028-10-15 (estimated)
Updated on ClinicalTrials.gov	2026-07-29