Clinical Trial

Finasteride and Cutibacterium

Not Yet Recruiting Phase 4
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Summary
High levels of Testosterone causes high amounts of skin bacteria (Cutibacterium Acnes) which can go into the skin during a shoulder replacement surgery and cause a terrible infection. The goal of this experiment is to have participants take Finasteride, a medication that blocks testosterone production, for 2 weeks and evaluate the following: * Blood levels of testosterone * Amount of bacteria on the skin. Participants will: * Be assigned to take Finasteride, or a placebo (a look-alike pill with no active medicine) once daily, for 2 weeks * Have a small sample of their blood collected and their skin swabbed with a Q-tip to determine Testosterone levels and bacteria on the skin * Blood draw and skin testing will take place before starting Finasteride or the placebo (day 0) and at the end of the experiment (day 14).
Trial Details
NCT Number NCT07731802
Lead Sponsor University of Washington
Conditions Dihydrotestosterone, Periprosthetic Joint Infection (PJI), Cutibacterium Acnes
Enrollment 40 participants
Start Date 2026-08-31
Primary Completion 2027-03-31 (estimated)
Study Completion 2027-08-31 (estimated)
Updated on ClinicalTrials.gov 2026-07-28