Clinical Trial

Glycemic Variability During Pregnancy After Bariatric Surgery

Completed
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Summary
Pregnancies after Metabolic and Bariatric Surgery (MBS) are linked to increased incidence of small-for-gestational-age (SGA) neonates. Hypoglycemia and glucose variability (GV) are known determinants of fetal growth; however, their impact on neonatal birth weight in pregnancies after MBS remains unclear. This study aims to assess whether glycemic profiles in these pregnancies are associated with fetal growth and to determine if specific GV parameters can predict growth restriction and SGA neonates. This is a single-center prospective cohort study of pregnant women previously post-MBS who underwent intermittently scanned continuous glucose monitoring (isCGM) once for trimester of pregnancy, allowing their glycemic profile to be analyzed. The primary aims of this study were to evaluate the extent to which the glycemic profile of pregnant women after MBS impacts fetal growth, and to identify which specific GV parameters may be used to predict fetal growth restriction and SGA neonates.
Trial Details
NCT Number NCT07731165
Lead Sponsor Centro Hospitalar Universitário de Santo António
Conditions Small Gestational Age (SGA), Hypoglycemia After Gastric Bypass, Glycemic Variability
Enrollment 47 participants
Start Date 2021-01-26
Primary Completion 2023-12-31 (estimated)
Study Completion 2025-09-30 (estimated)
Updated on ClinicalTrials.gov 2026-07-28