Clinical Trial

Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Otitis Media)

Study acronym: MEASURE
Not Yet Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
This study is being conducted at multiple hospitals and clinics to better understand whether antibiotics truly help children feel better when they have an ear infection (acute otitis media). Children in the study are randomly assigned (like flipping a coin) to receive either amoxicillin, amoxicillin-clavulanate, or a placebo (a look-alike medicine with no active antibiotic). Neither families nor study staff know which treatment the child is receiving during the study. The main goal is to compare how severe children's symptoms are each day while on these treatments. Parents or caregivers will report symptoms daily using a simple electronic diary. The study will also look at whether certain factors such as how sick the child is at the start, presence of fever, age, or how well antibiotics work. The results will help guide better treatment decisions for children with ear infections.
Trial Details
NCT Number NCT07730814
Lead Sponsor Nader Shaikh
Collaborators: Patient-Centered Outcomes Research Institute
Conditions Acute Otitis Media (AOM)
Enrollment 1,100 participants
Start Date 2026-10-01
Primary Completion 2031-12-18 (estimated)
Study Completion 2032-03-17 (estimated)
Updated on ClinicalTrials.gov 2026-07-28