Clinical Trial

Phase II Clinical Study on the Efficacy and Safety of QLS7305 in Patients With Kidney Disease (Part A)

Not Yet Recruiting Phase 2
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Summary
QLS7305 injection is a chemically synthesized double-stranded small interfering RNA (siRNA) targeting complement C3, covalently linked to a ligand containing N-acetylgalactosamine (GalNAc) residues. After subcutaneous (SC) administration, it can inhibit C3 synthesis through the RNA interference (RNAi) mechanism, reduce circulating C3 protein levels, decrease the generation of complement-activated C5 convertase, and inhibit complement pathway activation. It is expected to become an effective treatment for complement-mediated kidney diseases and hematological disorders.
Trial Details
NCT Number NCT07730632
Lead Sponsor Qilu Pharmaceutical Co., Ltd.
Conditions IgAN - IgA Nephropathy, Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN), C3 Glomerulopathy (C3G), Primary Membranous Nephropathy
Enrollment 60 participants
Start Date 2026-08-10
Primary Completion 2028-08-10 (estimated)
Study Completion 2028-08-11 (estimated)
Updated on ClinicalTrials.gov 2026-07-28