Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT07729982 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

A Longitudinal Natural History Study of OPA1-Associated Autosomal-Dominant Optic Atrophy

Study acronym: OPA-LONG
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

  1. Study First Submitted
This prospective, monocenter, non-interventional observational study investigates the natural history as well as the clinical and genetic spectrum of OPA1-associated autosomal dominant optic atrophy. Participants will undergo standardized ophthalmic and functional assessments, including visual acuity testing, visual field testing, color vision and contrast sensitivity testing, optical coherence tomography, retinal flavoprotein fluorescence imaging, and video-oculography-based ocular motor and pupillary measurements. The study aims to characterize disease severity and progression over time and to identify structural, metabolic, and functional biomarkers that may serve as clinical endpoints for future therapeutic studies.
Trial Details
NCT Number NCT07729982
Lead Sponsor Ludwig-Maximilians - University of Munich
Conditions
(from sponsor)		 OPA1 Gene Mutation, Optic Atrophy, Autosomal Dominant
Related terms Optic Atrophy, Autosomal Dominant
Enrollment 50 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov