A Comparative Study Between Rectal and Intrauterine Misoprostol Administration in the Reduction of Blood Loss During and After Elective Cesarean Delivery in Low Risk Women

One hundred forty low risk pregnant women scheduled for elective cesarean delivery were randomized (1:1) into two groups: the intrauterine group (n=70) received 400 μg misoprostol (200 μg at each uterine cornu) after placental delivery, while the rectal group (n=70) received 400 μg misoprostol rectally via urinary catheter insertion preoperatively.

NCT Number	NCT07728084
Lead Sponsor	Cairo University
Conditions	Postpartum Hemorrhage， Cesarean Section
Enrollment	140 participants
Start Date	2025-01-13
Primary Completion	2026-04-25 (estimated)
Study Completion	2026-06-29 (estimated)
Updated on ClinicalTrials.gov	2026-07-27