The Longitudinal Cohort of Cerebral Small Vessel Disease in Ruijin Hospital

The goal of this observational study is to learn about neuroimage and biomarkers in the cerebral small vessel disease. The main questions it aims to answer are: * How does neurovascular coupling change during the progression of CSVD? * How is the pattern/mapping of alterations in CSVD biomarkers? Participants will be observed and visit the research center annually to perform multi-modal MRI, PET, neuropsychological tests, and blood tests.

NCT Number	NCT07726654
Lead Sponsor	Ruijin Hospital
Conditions	Cerebral Small Vessel Disease
Enrollment	400 participants
Start Date	2026-07-08
Primary Completion	2028-09-30 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-24