Time-Restricted Eating and Staple Food Reduction Combined With App-Supported Exercise for Weight and Glycemic Control

This multicenter, three-arm randomized controlled trial will evaluate the effects of early time-restricted eating and staple food reduction, each combined with an app-supported exercise intervention, on body weight and glycemic control among adults with obesity and abnormal glucose metabolism. A total of 300 participants aged 18 to 50 years with BMI \>=28 kg/m2 and impaired glucose regulation or diabetes will be enrolled at five centers in China and randomized 1:1:1 to app-supported exercise alone, staple food reduction plus app-supported exercise, or early time-restricted eating plus app-supported exercise. The intervention lasts 12 weeks, followed by a 12-week post-intervention follow-up.

NCT Number	NCT07726615
Lead Sponsor	Peking University Collaborators: Chinese PLA General Hospital, Beijing Pinggu District Hospital, Dongying Traditional Chinese Medicine Hospital, Ningbo Beilun Community Health Service Center, Qingdao Municipal Hospital
Conditions	Obesity; Impaired Glucose Regulation; Prediabetes; Type 2 Diabetes Mellitus
Enrollment	300 participants
Start Date	2026-07
Primary Completion	2026-12 (estimated)
Study Completion	2027-04 (estimated)
Updated on ClinicalTrials.gov	2026-07-24