Effect of FPP on Cutaneous Barrier Integrity

This pilot study will test how Fermented Papaya Preparation (FPP) impacts overall TEWL of areas that commonly display diminished barrier function, such as the skin from face, arms, and hands. Areas of diminished barrier function are defined as those not visible to the eye but identified as areas of high transepidermal water loss (TEWL) as measured by a non-invasive pen-like device. A TEWL value of 20 or higher at a location would be considered high TEWL. Participants will attend 5 visits over 20 weeks, with 12-weeks of FPP treatment, and 8-weeks of follow-up.

NCT Number	NCT07725835
Lead Sponsor	University of Pittsburgh Collaborators: Osato Research Institute
Conditions	Skin Hydration in Healthy Volunteers
Enrollment	30 participants
Start Date	2026-07
Primary Completion	2028-04 (estimated)
Study Completion	2028-07 (estimated)
Updated on ClinicalTrials.gov	2026-07-24