A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative Colitis

Probiotics are live microorganisms that provide health benefits when consumed in sufficient amounts. Traditional probiotics, mainly from the Lactobacillus and Bifidobacterium genera, originate from fermented foods or the human gut and are widely used in supplements. Although considered safe and easy to produce, they are not specifically designed to treat diseases, and no official health claims have been approved by EFSA. Advances in microbiome research have led to the discovery of Next-Generation Probiotics (NGPs), which are newly identified gut microbes associated with health and offer promising therapeutic potential despite lacking a long history of safe use.

NCT Number	NCT07724990
Lead Sponsor	Catholic University of the Sacred Heart
Conditions	Ulcerative Colitis, Crohn Disease
Enrollment	20 participants
Start Date	2025-05-14
Primary Completion	2026-09-14 (estimated)
Study Completion	2027-05-14 (estimated)
Updated on ClinicalTrials.gov	2026-07-27