Clinical Trial

IOL Power Formula Prediction Accuracy at the Extremes of Axial Length: A Prospective Outcome Verification Study

Study acronym: FORMULEX-OV
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Summary
This single-center, prospective, cross-sectional study evaluates how accurately eight modern intraocular lens (IOL) power calculation formulas predicted the postoperative refractive result in eyes with extreme axial length after cataract surgery. Patients previously operated at the study center who had a very short (axial length \< 22.0 mm) or very long (\> 26.0 mm) eye and received a spherical monofocal IOL are invited to a single, non-invasive outcome visit. At this visit, standardized manifest refraction, optical biometry, corneal tomography, slit-lamp examination and, in long eyes, macular OCT are performed. The measured postoperative spherical equivalent is compared with the residual refraction that each of the eight formulas had predicted for the actually implanted IOL power, separately in short and long eyes. The study aims to identify which formula predicts the postoperative outcome most accurately at the extremes of axial length, where formula choice is most consequential and least well studied.
Trial Details
NCT Number NCT07724795
Lead Sponsor Vienna Hospital Association
Conditions Pseudophakia, Refractive Error
Enrollment 200 participants
Start Date 2026-08-01
Primary Completion 2027-06-01 (estimated)
Study Completion 2027-07-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-24