This study aims to evaluate the effects of 2 weeks of inulin supplementation in perimenopausal women with overweight or obesity. The primary questions this study seeks to answer are:
1. Does 2 weeks of inulin supplementation alter the gut and vaginal estrobolome compared with placebo?
2. Does 2 weeks of inulin supplementation affect cardiovascular health compared with placebo?
3. Does 2 weeks of inulin supplementation affect skeletal muscle health compared with placebo?
Researchers will compare inulin with a placebo (a similar-looking supplement that does not contain inulin) to determine whether inulin influences gut and vaginal microbial function, cardiovascular health, and skeletal muscle health during the perimenopausal transition.
Participants will:
* Take either inulin or a placebo for 2 weeks, followed by a 2- to 4-week washout period, and then switch to the other supplement for an additional 2 weeks.
* Attend 8 study visits over approximately 12 to 16 weeks for assessments and sample collection.
* Complete weekly phone calls to monitor symptoms, supplement adherence, and dietary intake.
* Wear a Fitbit device throughout the study to monitor physical activity.