Combating Age-related Failure of Myelination in Multiple Sclerosis: An Exploratory Study

This observational, longitudinal study will examine whether physical activity and other potentially modifiable lifestyle factors are associated with changes in myelin, the protective coating around nerve fibers, in older adults with multiple sclerosis (MS). Participants will undergo magnetic resonance imaging (MRI) scans to measure myelin throughout the central nervous system and will wear wrist-worn activity trackers to assess physical activity over time.

NCT Number	NCT07723599
Lead Sponsor	University of Washington
Conditions	Multiple Sclerosis
Enrollment	14 participants
Start Date	2026-08
Primary Completion	2027-06 (estimated)
Study Completion	2027-07 (estimated)
Updated on ClinicalTrials.gov	2026-07-23