Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training

The HyperLa study investigates whether a person's "glycolyticness"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training. Participants will undergo a specialized "vLapeak" test, which measures the maximal rate of lactate accumulation during a 10-second all-out cycling sprint, to determine their individual glycolytic power. Following this initial assessment, participants will complete eight weeks of standardized, twice-weekly resistance training focused on the lower body. The study aims to determine if individuals with higher initial vLapeak values experience greater increases in muscle size compared to those with lower values. This research may help explain why people respond differently to exercise and support the development of personalized training programs.

NCT Number	NCT07721766
Lead Sponsor	Technical University of Munich Collaborators: Chemnitz University of Technology, DLR German Aerospace Center, University of Jyvaskyla, University of Limerick, IST University of Applied Sciences Düsseldorf, Institute for Applied Training Science (IAT/FES e.V.)
Conditions	Healthy Volunteers, Muscle Hypertrophy, Glycolysis, Moderately Trainend
Enrollment	120 participants
Start Date	2026-05-04
Primary Completion	2026-12-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-23