Clinical Trial

Comparative Outcomes of Mammary Artery Harvesting: Infection, Occlusion Rates and Thoracic Pain Assessment

Study acronym: COMFORT

Withdrawn

View on ClinicalTrials.gov →

Why the trial stopped

Registered too early. Completing the vanguard first which is registered separately.

Summary

The COMFORT Trial is a randomized controlled superiority trial comparing skeletonized (SK) versus non-skeletonized (non-SK) harvesting of the left internal mammary artery (LIMA) to left anterior descending artery (LAD) graft in patients undergoing isolated coronary artery bypass grafting (CABG).

Protocol Amendment History 4 changes

critical Withdrawn before enrolling 2026-07-29

critical Trial withdrawn: Registered too early. Completing the vanguard first which is registered separately. 2026-07-29

critical Primary endpoint(s) modified 2026-07-29

notable Enrollment reduced: 1116 -> 0 participants 2026-07-29

Trial Details

NCT Number	NCT07720661
Lead Sponsor	Hamilton Health Sciences Corporation Collaborators: Population Health Research Institute
Conditions	Coronary Artery Disease, Coronary Artery Bypass Grafting, Surgical Site Infection
Start Date	2026-09-01
Primary Completion	2028-12-31 (estimated)
Study Completion	2029-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-28